Floor Guide
A complete breakdown of every floor in The Binding of Isaac: Rebirth, from the Basement to the Void.
Chapter 1
Basement / Cellar / Burning Basement
The first two floors. Enemies are weak and bosses are simple. Focus on collecting items and building your run.
- 1Explore every room to find the Item Room and Boss Room.
- 2Look for tinted rocks (marked with an X) to find Soul Hearts and Small Rock.
- 3The first floor always has a Treasure Room that does not require a key.
Chapter 2
Caves / Catacombs / Flooded Caves
Difficulty ramps up with tougher enemies and more complex room layouts. Bosses hit harder.
- 1Prioritize damage-up items to keep pace with enemy health scaling.
- 2Watch for spike rocks and environmental hazards.
- 3The shop becomes more valuable here. Carry keys for it.
Chapter 3
Depths / Necropolis / Dank Depths
Mid-game floors with significantly harder enemies. The Mom boss fight awaits at the end.
- 1Stock up on bombs for secret rooms and tinted rocks.
- 2Mom is a pattern-based boss. Learn her stomp and hand attack tells.
- 3After beating Mom, the way to Chapter 4 opens.
Chapter 4
Womb / Utero / Scarred Womb
Very dangerous floors with fast, aggressive enemies. Mom's Heart / It Lives is the main boss.
- 1Red hearts are rare here. Soul hearts and black hearts are critical.
- 2Enemies deal a full heart of damage. Defensive items shine.
- 3Beating Mom's Heart enough times unlocks alternate paths and endings.
Endgame
Cathedral / Sheol / Chest / Dark Room / Void
The final areas with the hardest bosses: Isaac, Satan, Blue Baby, The Lamb, and Delirium.
- 1Cathedral leads to the Chest (defeat Isaac then Blue Baby).
- 2Sheol leads to the Dark Room (defeat Satan then The Lamb).
- 3The Void can appear after any Chapter 4+ boss. Delirium awaits inside.
Special Rooms
Devil Room
Appears after boss fights with a chance based on not taking red heart damage. Items cost heart containers but are very powerful.
Angel Room
Replaces Devil Room chance after skipping a Devil deal. Contains free holy items. Can be blown open to access the angel boss for a key piece.
Secret Room
Hidden room adjacent to multiple rooms. Found by bombing walls. Contains random pickups, items, or special merchants.
Super Secret Room
One per floor, adjacent to only one room (usually at the edge of the map). Contains heart-related pickups.