èèåæã®é åçãªäžçãæ¢ããŸããå質管çãçèŽå€å®ãåœé貿æã«ãããéèŠæ§ãäž»èŠãªãã©ã¡ãŒã¿ãè©Šéšæ¹æ³ãåœéåºæºã«ã€ããŠè§£èª¬ã
èèåæã®æè¡ïŒã°ããŒãã«ãªèŠç¹ãã
ãããããäœãåºã倩ç¶ã®ç峿ã§ããèèã¯ããã®ç¬ç¹ã®é¢šå³ãæ é€äŸ¡ããããŠæœåšçãªå¥åº·å¹æããäžçäžã§çéãããŠããŸããããããäžçã®èèåžå Žã¯åœåãäžæ£è¡šç€ºããããŠäžè²«ããå質ã®ç¢ºä¿ãšãã£ã課é¡ã«çŽé¢ããŠããŸããããã§æŽ»èºããã®ããèèåæã®æè¡ãšç§åŠã§ãããã®å æ¬çãªã¬ã€ãã§ã¯ããã®éèŠæ§ãæ¹æ³ãåœéåºæºãç¶²çŸ ããã°ããŒãã«ãªèŠç¹ããèèåæã®äž»èŠãªåŽé¢ãæ¢ããŸãã
ãªãèèåæã¯éèŠãªã®ãïŒ
èèåæã極ããŠéèŠã§ããçç±ã¯ããã€ããããŸãïŒ
- å質管çïŒèèãç¹å®ã®åè³ªåºæºãèŠå¶ãæºãããŠããããšãä¿èšŒããæ¶è²»è ãå®å šã§æ¬ç©ã®è£œåãåãåããããã«ããŸãã
- çèŽå€å®ïŒèèã®åç£å°ãè±ã®çš®é¡ãçŽåºŠãæ€èšŒããå®äŸ¡ãªç峿ã«ããåœåãªã©ã®äžæ£è¡çºãé²ããŸãã
- 貿æãšåæ¥ïŒèèã®å質ãè©äŸ¡ãã茞åºå ¥èŠä»¶ãæºããããã®å ±éåºç€ãæäŸããããšã§ãåœé貿æãä¿é²ããŸããåœã«ãã£ãŠåºæºã¯ç°ãªããŸããäŸãã°ã欧å·é£åã«ã¯ç¬èªã®èŠå¶ããããç±³åœã«ãç¬èªã®èŠå¶ããããŸãã
- æ¶è²»è ä¿è·ïŒèª€è§£ãæã衚瀺ããæ¶è²»è ãä¿è·ããæ¯æã£ã察䟡ã«èŠåãèèã確å®ã«æã«å ¥ããããããã«ããŸãã
- é€èã®å®è·µïŒåæã«ãããèã®ã³ãããŒã®å¥åº·ç¶æ ãèæºã®è³ªã«é¢ããæŽå¯ãåŸãããšãã§ããŸãã
èèåæã«ãããäž»èŠãªãã©ã¡ãŒã¿
èèåæã§ã¯ããã®å質ãšçæ£æ§ãè©äŸ¡ããããã«ãããã€ãã®äž»èŠãªãã©ã¡ãŒã¿ãè©äŸ¡ããŸãããããã®ãã©ã¡ãŒã¿ã«ã¯ä»¥äžãå«ãŸããŸãïŒ
1. æ°Žå嫿é
èèã®æ°Žå嫿éã¯ããã®å®å®æ§ãšä¿åæéã®éèŠãªææšã§ããæ°Žå嫿éãé«ããšãçºé µãè æã«ã€ãªããå¯èœæ§ããããŸããã»ãšãã©ã®åœéåºæºã§ã¯ãæå€§æ°Žå嫿éã20%ãšå®ããŠããŸããæ°Žå嫿éã®æž¬å®ã«ã¯äžè¬çã«å±æèšã䜿çšããã屿çãæ°Žå嫿éãšçŽæ¥çžé¢ããŠããŸãã
äŸïŒæ±åã¢ãžã¢ã®äžéšã®ãããªæ¹¿åºŠã®é«ãå°åã§æ¡ããèèã¯ãæ°Žå嫿éãæžãããŠçºé µãé²ãããã«ãããæ éãªåŠçãå¿ èŠã«ãªãããšããããããŸãã
2. ç³çµæ
èèã¯äž»ã«ç³ãç¹ã«æç³ãšãããŠç³ã§æ§æãããŠããŸãããããã®ç³ã®æ¯çããã·ã§ç³ã麊èœç³ãªã©ã®ä»ã®ç³ã®ååšã¯ãèèã®è±ã®çš®é¡ãåœåã®å¯èœæ§ã«é¢ããæ å ±ãæäŸããŸããç³çµæã®æ±ºå®ã«ã¯ãé«éæ¶²äœã¯ãããã°ã©ãã£ãŒïŒHPLCïŒãäžè¬çãªæ¹æ³ã§ãã
äŸïŒãã¥ãŒãžãŒã©ã³ãç£ã®ããã«ãããŒã¯ç¬ç¹ã®ç³çµæãæã¡ããã®æèç¹æ§ã«å¯äžããã¡ãã«ã°ãªãªããµãŒã«ïŒMGOïŒãå«ãã§ããŸããããã¯ãã®äŸ¡å€ã«ãããéèŠãªèŠçŽ ã§ãã
3. ããããã·ã¡ãã«ãã«ãã©ãŒã«ïŒHMFïŒ
HMFã¯ãèèãå ç±ãããããé·æéä¿åãããããããšçæãããååç©ã§ããHMFã®ã¬ãã«ãé«ãããšã¯ãéç±ãäžé©åãªä¿ç®¡ããŸãã¯åœåã瀺ããŸããåœéåºæºã§ã¯ãã»ãšãã©ã®èèã¿ã€ãã§HMFã40 mg/kgã«å¶éããŠããŸãããäžéšã®å°åã§ã¯ããšãŒãããã®ç¹å®åžå Žåãã®èèã«å¯ŸããŠ10 mg/kgãªã©ãããå³ããå¶éãèšããŠããå ŽåããããŸãã
äŸïŒçµæ¶åãé²ãããã«ããè¡ãããå å·¥äžã®é床ãªå ç±ããããèèã¯ãHMFã¬ãã«ãäžæããŸãã
4. ãžã¢ã¹ã¿ãŒãŒæŽ»æ§
ãžã¢ã¹ã¿ãŒãŒã¯èèã«å€©ç¶ã«ååšããé µçŽ ã§ãèã®åŠçäžã«ããããã®åŸæ¶²ããç±æ¥ããŸãããžã¢ã¹ã¿ãŒãŒæŽ»æ§ã¯å ç±ãé·æä¿åã«ãã£ãŠäœäžããŸããäœããžã¢ã¹ã¿ãŒãŒäŸ¡ã¯ãèèãé床ã«å ç±ãããããäžé©åã«ä¿ç®¡ãããããšã瀺ããŸãããžã¢ã¹ã¿ãŒãŒæŽ»æ§ã®æž¬å®ã«ã¯ãéåžžãã·ã£ãŒãæ³ãçšããããŸãã
äŸïŒãšãŒãããã®åºæºã§ã¯ãé«å質ãšèŠãªãããèèã«ã¯ããã°ãã°æäœ8ã·ã£ãŒãåäœã®ãžã¢ã¹ã¿ãŒãŒæŽ»æ§ãèŠæ±ãããŸãã
5. è±ç²åæïŒã¡ãªãœããªãããžãŒïŒ
è±ç²åæã§ã¯ãèèäžã«ååšããè±ç²ç²ãç¹å®ããå®éåããŸãããã®æè¡ã«ãããèèã®è±ã®çš®é¡ãšå°ççèµ·æºãç¹å®ã§ããŸããããã¯ãç¹ã«åè±èã®çæ£æ§ãšæ€ç©åŠçèµ·æºãæ€èšŒããããã®éèŠãªããŒã«ã§ããè±ç²ç²ã®åœ¢æ ã«åºã¥ããŠç¹å®ããããã«é¡åŸ®é¡ã䜿çšãããŸãã
äŸïŒèèäžã®ã©ãã³ããŒã®è±ç²ãç¹å®ããããšã§ãããããã©ã³ã¹ã®ãããŽã¡ã³ã¹å°æ¹ãªã©ãã©ãã³ããŒãè±å¯ã«çè²ããå°åãåç£ãšãããæ£çæ£éã®ã©ãã³ããŒãããŒã§ããããšã確èªã§ããŸãã
6. 黿°äŒå°åºŠ
黿°äŒå°åºŠïŒECïŒã¯ãèèã黿°ãéãèœåãæž¬å®ããŸããããã¯èèã®ããã©ã«ãšé žã®å«æéã«é¢é£ããŠãããè±ã®çš®é¡ãåºå¥ããããã«äœ¿çšã§ããŸããçé²èã®ãããªããã©ã«å«æéã®é«ãèèã¯ãéåžžãããé«ã黿°äŒå°åºŠã瀺ããŸãã
äŸïŒæš¹æšã§é€åãæãæè«ã®åæ³ç©ããäœãããçé²èã¯ãè±ã®èããäœãããèèãããèããé«ã黿°äŒå°åºŠãæã¡ãŸãã
7. é žåºŠ
èèã®é žåºŠã¯ãã°ã«ã³ã³é žãªã©ã®ææ©é žã®ååšã«ãããã®ã§ããé床ã®é žåºŠã¯çºé µãè æã瀺ãããšããããŸããèèã®é žåºŠã枬å®ããããã«ã¯æ»Žå®ãçšããããŸãã
äŸïŒpHã3.5æªæºã®èèã¯çºé µããããå¯èœæ§ããããŸãã
8. æçç©è³ªæ®çç©
èèäžã®æçç©è³ªæ®çç©ã®ååšã¯ãæœåšçãªå¥åº·ãªã¹ã¯ãšæçç©è³ªèæ§èã®çºçã®ããæžå¿µãããŠããŸããå€ãã®åœã§ã¯ãé€èã«ãããæçç©è³ªã®äœ¿çšãšèèäžã®èš±å®¹æ®çã¬ãã«ã«é¢ããŠå³ããèŠå¶ãèšããŠããŸããæçç©è³ªæ®çç©ã®æ€åºã«ã¯ãæ¶²äœã¯ãããã°ã©ãã£ãŒè³ªéåææ³ïŒLC-MSïŒã䜿çšãããŸãã
äŸïŒæ¬§å·é£åã¯é€èã«ãããç¹å®ã®æçç©è³ªã®äœ¿çšãçŠæ¢ããŠãããEUã«èŒžå ¥ãããèèã¯æçç©è³ªã®æå€§æ®çåºæºå€ïŒMRLïŒã«æºæ ããå¿ èŠããããŸãã
9. ééå±
èèã¯ãç°å¢æ±æãé€èã®å®è·µããééå±ã§æ±æãããå¯èœæ§ããããŸããé«ã¬ãã«ã®ééå±ã¯å¥åº·ãªã¹ã¯ãããããå¯èœæ§ããããŸããèèäžã®ééå±ã¬ãã«ã枬å®ããããã«ãèªå°çµåãã©ãºã質éåææ³ïŒICP-MSïŒã䜿çšãããŸãã
äŸïŒå·¥æ¥å°åž¯ã®è¿ãã§çç£ãããèèã¯ãéãã«ãããŠã ãªã©ã®ééå±ã®ã¬ãã«ãé«ãå ŽåããããŸãã
10. å®èœè©äŸ¡
å®èœè©äŸ¡ã§ã¯ãèèã®å€èгãéŠããå³ã質æãè©äŸ¡ããŸããèšç·Žããããããªã¹ãããããã®ç¹æ§ãè©äŸ¡ããèèã®å šäœçãªå質ã倿ããæ¬ é¥ãç¹å®ããŸãã
äŸïŒèšç·Žãããèèéå®å£«ã¯ãã©ãã³ããŒãããŒã®è±ã®ãããªéŠããããã°èèã®ãããã®ãããªé¢šå³ãªã©ãç¬ç¹ã®ãã¬ãŒããŒãããã¡ã€ã«ã«åºã¥ããŠç°ãªãè±ã®çš®é¡ãåºå¥ããããšãã§ããŸãã
èèåæã§çšããããäžè¬çãªæ¹æ³
èèã®æ§ã ãªãã©ã¡ãŒã¿ãè©äŸ¡ããããã«ãããã€ãåææ¹æ³ã䜿çšãããŸãïŒ
- å±æèšæ³ïŒæ°Žå嫿éã®æž¬å®ã«äœ¿çšãããŸãã
- é«éæ¶²äœã¯ãããã°ã©ãã£ãŒïŒHPLCïŒïŒç³çµæã®æ±ºå®ã«äœ¿çšãããŸãã
- åå å 床æ³ïŒHMF嫿éã®æž¬å®ã«äœ¿çšãããŸãã
- ã·ã£ãŒãæ³ïŒãžã¢ã¹ã¿ãŒãŒæŽ»æ§ã®æž¬å®ã«äœ¿çšãããŸãã
- é¡åŸ®é¡æ³ïŒè±ç²åæïŒã¡ãªãœããªãããžãŒïŒã«äœ¿çšãããŸãã
- 黿°äŒå°åºŠæž¬å®æ³ïŒé»æ°äŒå°åºŠã®æž¬å®ã«äœ¿çšãããŸãã
- æ»Žå®æ³ïŒé žåºŠã®æž¬å®ã«äœ¿çšãããŸãã
- æ¶²äœã¯ãããã°ã©ãã£ãŒè³ªéåææ³ïŒLC-MSïŒïŒæçç©è³ªæ®çç©ã®æ€åºã«äœ¿çšãããŸãã
- èªå°çµåãã©ãºã質éåææ³ïŒICP-MSïŒïŒééå±ã¬ãã«ã®æž¬å®ã«äœ¿çšãããŸãã
- å®èœè©äŸ¡ïŒå€èгãéŠããå³ã質æã®è©äŸ¡ã«äœ¿çšãããŸãã
åœéåºæºãšèŠå¶
ããã€ãã®åœéæ©é¢ãèŠå¶æ©é¢ããèèã®å質ãšçæ£æ§ã«é¢ããåºæºãèŠå¶ã確ç«ããŠããŸãããããã®åºæºã¯åœã«ãã£ãŠç°ãªããŸãããäžè¬çãªãã®ã«ã¯ä»¥äžãå«ãŸããŸãïŒ
- ã³ãŒããã¯ã¹ã»ã¢ãªã¡ã³ã¿ãªãŠã¹ïŒé£ç³§èŸ²æ¥æ©é¢ïŒFAOïŒãšäžçä¿å¥æ©é¢ïŒWHOïŒã«ãã£ãŠèšç«ãããã³ãŒããã¯ã¹ã»ã¢ãªã¡ã³ã¿ãªãŠã¹å§å¡äŒã¯ãèèã®åºæºãå«ãåœéçãªé£ååºæºãèšå®ããŠããŸãããããã®åºæºã¯ãæ°Žå嫿éãç³çµæãHMFã¬ãã«ããžã¢ã¹ã¿ãŒãŒæŽ»æ§ãªã©ãèèã®åè³ªã®æ§ã ãªåŽé¢ãã«ããŒããŠããŸãã
- 欧å·é£åïŒEUïŒèèæä»€ïŒEUã¯èèæä»€ïŒ2001/110/ECïŒã§æŠèª¬ãããŠããèèã«é¢ããç¹å®ã®èŠå¶ãæã£ãŠããŸãããã®æä»€ã¯ãèèã®çµæã衚瀺ãçæ£æ§ã«é¢ããåºæºãèšå®ããŠããŸãããŸããæçç©è³ªã蟲è¬ãªã©ã®æ±æç©è³ªã®æå€§æ®çåºæºå€ãå®ããŠããŸãã
- ç±³åœèŸ²åçïŒUSDAïŒïŒUSDAã¯ãè²ãéæåºŠã颚å³ãªã©ã®èŠçŽ ã«åºã¥ããèèã®ççŽåºæºã確ç«ããŠããŸãããããã®åºæºã¯ä»»æã§ãããç±³åœã®èèåžå Žã§åºã䜿çšãããŠããŸãã
- ååœã®ãããŒããŒãããã³åäŒïŒå€ãã®åœã«ã¯ãèèã®å質ãä¿é²ããé€èå®¶ãèèçç£è ã«ã¬ã€ãã³ã¹ãæäŸããåœç«ã®ãããŒããŒããåäŒããããŸãããããã®çµç¹ã¯ãç¬èªã®åè³ªåºæºãèªèšŒããã°ã©ã ã確ç«ããããšããããããŸãããã¥ãŒãžãŒã©ã³ãã®UMFãããŒåäŒã¯ãã®ä»£è¡šçãªäŸã§ãã
èèåæã«ããã課é¡
èèåææè¡ã®é²æ©ã«ãããããããããã€ãã®èª²é¡ãæ®ã£ãŠããŸãïŒ
- åœåïŒå®äŸ¡ãªç峿ã«ããèèã®åœåãå¢å ããŠãããããäžæ£è¡çºã®æ€åºãå°é£ã«ãªã£ãŠããŸãã
- è€éæ§ïŒèèã¯è€éãªãããªãã¯ã¹ã§ããããã®æ§ã ãªæåãåæããã«ã¯ãé«åºŠãªåææè¡ãšå°éç¥èãå¿ èŠã§ãã
- ã³ã¹ãïŒLC-MSãICP-MSãªã©ã®äžéšã®åææ¹æ³ã¯é«äŸ¡ã§ãããããå°èŠæš¡ãªçç£è ã«ã¯å©çšãã«ããå ŽåããããŸãã
- æšæºåã®æ¬ åŠïŒäžéšã®åææ¹æ³ã«ã¯æšæºåãæ¬ ããŠãããç°ãªãç ç©¶æéã§çµæã«ã°ãã€ããçããŸãã
- æ°ããªæ±æç©è³ªïŒèŸ²è¬ãåç©çšå»è¬åãªã©ãæ°ããªæ±æç©è³ªãçµ¶ããåºçŸããŠãããæ°ããåææ¹æ³ã®éçºãæ±ããããŠããŸãã
èèåæã®å°æ¥ã®åå
èèåæã®åéã¯çµ¶ããé²åããŠããã課é¡ã«å¯ŸåŠããèèåæã®ç²ŸåºŠãšä¿¡é Œæ§ãåäžãããããã®æ°ããæè¡ãææ³ãç»å ŽããŠããŸããå°æ¥ã®ååã«ã¯ä»¥äžã®ãããªãã®ããããŸãïŒ
- é«åºŠãªåææè¡ïŒæ žç£æ°å ±é³ŽïŒNMRïŒåå æ³ãå®å®åäœäœæ¯åæïŒSIRAïŒãªã©ã®é«åºŠãªåææè¡ã®äœ¿çšããèèã®çèŽå€å®ãåç£å°æ±ºå®ã®ããã«ãŸããŸãäžè¬çã«ãªã£ãŠããŸãã
- è¿ éãã€ããŒã¿ãã«ãªæ¹æ³ã®éçºïŒçŸå Žã§ã®èèå質è©äŸ¡ã«äœ¿çšã§ãããè¿ éãã€ããŒã¿ãã«ãªåææ¹æ³ãžã®éèŠãé«ãŸã£ãŠããŸããè¿èµ€å€åå æ³ïŒNIRSïŒã¯ãã®ç®çã®ããã®ææãªæè¡ã§ãã
- ããã°ããŒã¿ãšäººå·¥ç¥èœïŒããã°ããŒã¿åæãšäººå·¥ç¥èœïŒAIïŒã®å¿çšã¯ãèèåæããŒã¿ã®ãã¿ãŒã³ãåŸåãç¹å®ããåœåã®æ€åºãèèå質ã®äºæž¬ãåäžãããã®ã«åœ¹ç«ã¡ãŸãã
- ãããã¯ãã§ãŒã³æè¡ïŒãããã¯ãã§ãŒã³æè¡ã䜿çšããŠãèèã®éæã§å®å šãªãµãã©ã€ãã§ãŒã³ãæ§ç¯ãã巣箱ããæ¶è²»è ãŸã§ã®åç£å°ãšçæ£æ§ã远跡ããããšãã§ããŸãã
é€èå®¶ãçç£è ãæ¶è²»è ã®ããã®å®è·µçãªæŽå¯
é€èå®¶åãïŒ
- æè¯ã®å®è·µãå°å ¥ããïŒã³ãããŒã®å¥åº·ãšèèã®å質ã確ä¿ããããã«ãæè¯ã®é€èæ £è¡ã«åŸã£ãŠãã ãããããã«ã¯ãé©åãªå·£ç®±ç®¡çãç 害察çã責任ããæçç©è³ªã®äœ¿çšãå«ãŸããŸãã
- èèã®å質ãç£èŠããïŒæ°Žå嫿éãHMFã¬ãã«ããžã¢ã¹ã¿ãŒãŒæŽ»æ§ãªã©ã®äž»èŠãªãã©ã¡ãŒã¿ããã¹ãããŠã宿çã«èèã®å質ãç£èŠããŠãã ããã
- æ£ç¢ºã«è¡šç€ºããïŒè±ã®çš®é¡ãå°ççèµ·æºã䜿çšãããå å·¥æ¹æ³ãªã©ãæ£ç¢ºã§éææ§ã®é«ã衚瀺æ å ±ãæäŸããŠãã ããã
çç£è åãïŒ
- å質管çããã°ã©ã ã確ç«ããïŒèèãåœéçãªåºæºãèŠå¶ãæºãããŠããããšãä¿èšŒããããã«ãå ç¢ãªå質管çããã°ã©ã ãå°å ¥ããŠãã ããã
- åææ©åšã«æè³ããïŒç€Ÿå ã§èèåæãè¡ãããã®åææ©åšã«æè³ããããä¿¡é Œã§ããæ€æ»æ©é¢ãšææºããŠãã ããã
- ãã¬ãŒãµããªãã£ã·ã¹ãã ãå°å ¥ããïŒèèã®åç£å°ãšå å·¥ã远跡ããããã®ãã¬ãŒãµããªãã£ã·ã¹ãã ãå°å ¥ããæ¶è²»è ã«ãã®çæ£æ§ã«å¯Ÿããä¿¡é ŒãæäŸããŠãã ããã
æ¶è²»è åãïŒ
- ä¿¡é Œã§ããäŸçµŠæºããè³Œå ¥ããïŒå°å ã®é€èå®¶ãè©å€ã®è¯ããã©ã³ãããŸãã¯èªå®ãããææ©çç£è ãªã©ãä¿¡é Œã§ããäŸçµŠæºããèèãè³Œå ¥ããŠãã ããã
- ã©ãã«ãæ³šææ·±ãèªãïŒè±ã®çš®é¡ãå°ççèµ·æºã䜿çšãããå å·¥æ¹æ³ãçè§£ããããã«ãã©ãã«ãæ³šææ·±ãèªãã§ãã ããã
- èªèšŒãæ¢ãïŒããã«ãããŒã®UMFãªã©ãèèããã¹ããããç¹å®ã®åè³ªåºæºãæºãããŠããããšã瀺ãèªèšŒããŒã¯ãæ¢ããŠãã ããã
- äŸ¡æ Œã«æ³šæããïŒåžå Žå¹³åãããèããå®ãäŸ¡æ Œã®èèã«ã¯æ³šæããŠãã ãããåœåãããŠããå¯èœæ§ããããŸãã
çµè«
èèåæã¯ãäžçã®åžå Žã«ãããŠèèã®å質ãçæ£æ§ãå®å šæ§ã確ä¿ããããã®éèŠãªèŠçŽ ã§ããäž»èŠãªãã©ã¡ãŒã¿ãè©Šéšæ¹æ³ãåœéåºæºãçè§£ããããšã§ãé€èå®¶ãçç£è ãæ¶è²»è ã¯ååããŠããã®è²Žéãªå€©ç¶ç£ç©ã®å®å šæ§ãç¶æããããšãã§ããŸããæè¡ã鲿©ããæ°ããªèª²é¡ãåºçŸããã«ã€ããŠãèèåæã®åéã¯é²åãç¶ããæ¶è²»è ãä¿è·ããäžçäžã§æç¶å¯èœãªé€èãæ¯æŽããäžã§äžå¯æ¬ ãªåœ¹å²ãæãããŠããã§ãããã
ãã®ã¬ã€ãã§æäŸãããæ å ±ã¯æ å ±æäŸã®ã¿ãç®çãšããŠãããå°éçãªã¢ããã€ã¹ãšèŠãªãããã¹ãã§ã¯ãããŸãããç¹å®ã®èèåæã®ããŒãºã«ã€ããŠã¯ãå¿ ãè³æ Œã®ããå°éå®¶ã«ãçžè«ãã ããã