Character Guides

All playable characters in The Binding of Isaac: Rebirth grouped by difficulty.

Easy

Isaac

Starting Item: The D6

The default character with balanced stats. Starts with The D6 after unlocking it, allowing rerolls of item pedestals for better options.

Magdalene

Starting Item: Yum Heart

A tanky character with extra health and the Yum Heart active item, which heals one red heart container on use. Great for beginners.

Azazel

Starting Item: Mini Brimstone

Starts with flight and a short-range Brimstone laser. Very powerful in early floors but the short range becomes a challenge later.

Medium

Cain

Starting Item: Lucky Foot

Starts with higher luck and the Lucky Foot trinket, which improves pill outcomes and room rewards. Lower health but better drops.

Eve

Starting Item: Whore of Babylon

Gains a significant damage boost when at half a heart or less via Whore of Babylon. Rewards risky, low-health playstyles.

Samson

Starting Item: Bloody Lust

Gains a temporary damage boost for each enemy killed in a room through Bloody Lust. Excels in rooms with many enemies.

Lazarus

Starting Item: Lazarus Rags

Revives with increased damage upon death thanks to Lazarus Rags. Essentially gives two attempts at each run.

Eden

Starting Item: Random

Starts with completely randomized stats and items each run. Requires an Eden Token to play. Every run is a unique experience.

Lilith

Starting Item: Box of Friends

Blindfolded and cannot shoot directly. Relies on an Incubus familiar to deal damage. Box of Friends doubles all familiars for the current room.

Apollyon

Starting Item: Void

Starts with the Void active item, which absorbs other items and gains their passive effects or triggers their active effects on use.